BIOS

BIOS is leading a scientific revolution to create a healthier and happier future. Read the studies that are paving the way.

Circadian Drive, Alertness and Mental Performance

A time to remember – the role of circadian clocks in learning and memory
Download PDF

Amplitude Reduction and Phase Shifts of Melatonin, Cortisol and Other Circadian Rhythms after a gradual Advance of Sleep and Light Exposure in Humans
Download PDF

Environmental 24-hr Cycles Are Essential for Health
Download PDF

Improved neurobehavioral performance during the wake maintenance zone
Download PDF

Investigating the interaction between the homeostatic and circadian processes of sleep-wake regulation for the prediction of waking neurobehavioral performance
Download PDF

Modeling Napping, Post-Lunch Dip, and Other Variations in Human Sleep Propensity
Download PDF

Morning Sleep Inertia in Alertness and Performance – Effect of Cognitive Domain and White Light Conditions
Download PDF

Relationship between alertness, performance, and body temperature in humans
Download PDF

Short Wavelength Light Enhances Cortisol Awakening Response in Sleep-Restricted Adolescents
Download PDF

Systems Biology of Circadian Rhythms – An Outlook
Download PDF

The Cortisol Awakening Response – Facts and Future Directions
Download PDF

The cortisol awakening response – more than a measure of HPA axis function
Download PDF

The forbidden zone for sleep and its biological purpose is to enhance survival
Download PDF

Time to decide – diurnal variation on the speed and quality of human decisions
Download PDF

Timing and Consolidation of Human Sleep, Wakefulness, and Performance by a Symphony of Oscillators
Download PDF

Social Jet Lag and Light at Night

Ancestral sleep
Download PDF

Circadian Entrainment to the Natural Light-Dark Cycle Across Seasons and the Weekend
Download PDF

Crosstalk Between Environmental Light and Internal Time in Humans
Download PDF

Digital Sleep Logs Reveal Potential Impacts of Modern Temporal Structure on Class Performance in Different Chronotypes
Download PDF

Endocrine Effects of Circadian Disruption
Download PDF

Entrainment of the Human Circadian Clock to the Natural Light-Dark Cycle
Download PDF

Evening use of light-emitting eReaders negatively affects sleep, circadian timing, and next-morning alertness
Download PDF

Global rise of potential health hazards caused by blue light-induced circadian disruption in modern aging societies
Download PDF

Light Hygiene – Time to make preventative use of insights – old and new – into the nexus of the drug light, melatonin, clocks, chronodisruption and public health
Download PDF

Nocturnal light pollution and underexposure to daytime sunlight Complementary mechanisms of circadian disruption and related diseases
Download PDF

Protecting the Melatonin Rhythm through Circadian Healthy Light Exposure
Download PDF

Sleep Fragmentation and the risk of Incident Alzheimer’s Disease and Cognitive Decline in Older Persons
Download PDF

Sleep in adolescents – the perfect storm
Download PDF

Social Jet Lab and Obesity
Download PDF

Social Jetlag – Misalignment of Biological and Social Time
Download PDF

Synchronization of biological clock neurons by light and peripheral feedback systems promotes circadian rhythms and health
Download PDF

The Circadian Clock and Human Health
Download PDF

The effects of self-selected light-dark cycles and social constraints on human sleep and circadian timing – a modeling approach
Download PDF

Field Applications and Studies

A 10am School Start Time Improves Health and Performance of Students Aged 13-16
Download PDF

Aging Reduces the Stimulating Effect of Blue Light on Cognitive Brain Functions
Download PDF

Alzheimers pilot study
Download PDF

Buying Time – a rationale for examining the use of circadian rhythm and sleep interventions to delay progression of mild cognitive impairment to Alzheimers disease
Download PDF

Circadian timing and age
Download PDF

Correcting Delayed Circadian Phase with Bright Light Therapy Predicts Improvement in ADHD Symptoms
Download PDF

Decreased Sensitivity to Phase Delaying Effects of Moderate intensity light in older subjects
Download PDF

Irregular sleep wake patterns are associated with poorer academic performance and delayed circadian and sleep-wake timing
Download PDF

Lower School Performance in Late Chronotypes – Underlying Factors and Mechanisms
Download PDF

Progression of Dementia Assessed by Temporal Correlations of Physical Activity – Results from a 3_5 year, longitudinal randomized controlled trial
Download PDF

Lighting Design Parameters

Color and spectral analysis of daylight in southern Europe
Download PDF

Dim light adaptation attenuates acute melatonin suppression in humans
Download PDF

Direct Effects of Light on Alertness, Vigilance, and the Waking EEG in Humans Depend on Prior Light History
Download PDF

Inferior Retinal Light Exposure is More Effective than Superior Retinal Exposure in Suppressing Melatonin in Humans
Download PDF

Melatonin Suppression by Illumination of Upper and Lower Visual Fields
Download PDF

Peripheral Vision Suppression of Melatonin
Download PDF

The Human Circadian System Adapts to Prior Photic History
Download PDF

Circadian Photoreception

Action Spectrum for melatonin regulation in humans – evidence for a novel circadian photoreceptor
Download PDF

An action spectrum for melatonin suppression – evidence for a novel non-rod, non-cone photoreceptor system in humans
Download PDF

Dim light adaptation attenuates acute melatonin suppression in humans
Download PDF

Human responses to bright light of different durations
Download PDF

Mammalian Inner Retinal Photoreception
Download PDF

Measuring and using light in the melanopsin age
Download PDF

Melanopsin-containing retinal ganglion cells – architecture, projections, and intrinsic photosensitivity
Download PDF

Phototransduction by Retinal Ganglion Cells that Set the Circadian Clock
Download PDF

Short Wavelength enrichment of polychromatic light enhances human melatonin suppression potency
Download PDF

Signalling by melanopsin (OPN4) expressing photosensitive retinal ganglion cells
Download PDF

Suppression of melatonin secretion in some blind patients by exposure to bright light
Download PDF

Using light to tell time of day – sensory coding in the mammalian circadian visual network
Download PDF

Bad Blue

The stimulating effect of bright light on physical performance depends on internal time
Download PDF

Effects of blue light on the circadian system and eye physiology
Download PDF

Effects of light-emitting dioge radiations on human retinal pigment epithelial cells in vitro
Download PDF

Light emitting diodes for domestic lighting – any risks for the eye?
Download PDF

Light induced retinal damage using different light sources, protocols and rat strains reveals led phototoxicity
Download PDF

Retinal damage induced by commercial light emitting diodes
Download PDF

The susceptibility of the retina to photochemical damage from visible light
Download PDF

White light emitting diodes at domestic lighting levels and retinal injury in a rat model
Download PDF

Skin Response and Far-red benefits

670nm light mitigates oxygen-induced degeneration in mouse retina
Download PDF

A controlled trial to determine the efficacy of red and near-infrared light treatment in patient satisfaction, reduction of fine lines, wrinkles, skin roughness, and intradermal collagen density increase
Download PDF

Aging retinal function is improved by near infrared light 670nm that is associated with corrected mitochrondrial decline
Download PDF

Differential effects of 670 and 830nm therapy – a comparative study of optic nerve injury, retinal degeneration, traumatic brain and spinal cord injury
Download PDF

Lighting for clinical observation of cyanosis
Download PDF

Low infra red laser light irradiation on cultured neural cells – effects on mitochrondria and cell viability after oxidative stress
Download PDF

Low level light therapy increases mitochondrial membrane potential and ATP synthesis in C2C12 myotubes with a peak response at 3-6 hours
Download PDF

Multiple roles of cytochrome c oxidase in mammalian cells uner action of red and ir-a radiation
Download PDF

Photobiomodulation in human muscle tissue – an advantage in sports performance
Download PDF

Regulation of skin collagen metabolism in vitro using a 660nm LED light source – clinical correlation with a single-blinded study
Download PDF

Circadian Athletic and Sports Performance

Circadian variation in swim performance
Download PDF

Circadian disruption and remedial interventions
Download PDF

Circadian rhythms and enhanced athletic performance in the national football league
Download PDF

Circadian rhythms in exercise performance – implications for hormonal and muscular adaptation
Download PDF

Impact of the human circadian system, exercise, and their interaction on cardiovascular function
Download PDF

The effects of sleep extension on the athletic performance of collegiate basketball players
Download PDF

The stimulating effect of bright light on physical performance depends on internal time
Download PDF

Seasonality

Long Days Enhance Recognition Memory and Increase Insulin-like growth factor 2 in the hippocampus
Download PDF

Twilight

A colourful clock – van Diepen, Foster, Meijer – 2015
Download PDF

Dawn and dusk simulation as a therapeutic intervention
Download PDF

Impaired Circadian Photoentrainment in Opn-5 Null Mice
Download PDF

Melanopsin-driven increases in maintained activity enhance thalamic visual response reliability across a simulat – Storchi et al. – 2015
Download PDF

Twilights widen the range of photic entrainment in hamsters
Download PDF

Ultraviolet light provides a major input to non-image-forming light detection in mice – Van Oosterhout et al. – 2012
Download PDF